OrangerV1, Main, Exploration, bibRecord, 000A90

Evaluation of the anti-proliferative and cytostatic effect of Citrus sinensis (orange) fruit juice

Identifieur interne : 000A90 ( Main/Exploration ); précédent : 000A89; suivant : 000A91

Evaluation of the anti-proliferative and cytostatic effect of Citrus sinensis (orange) fruit juice

Auteurs : Enegide Chinedu [Nigeria] ; David Arome [Nigeria] ; Solomon F. Ameh [Nigeria] ; Gift E. Ameh [Nigeria]

Source :

International Journal of Applied and Basic Medical Research [ 2229-516X ] ; 2014.

RBID : PMC:4181126

Abstract

Aim:

This work has been designed to evaluate the anti-proliferative and cytostatic effects of Citrus sinensis (orange) fruit juice on rapidly proliferating cells.

Materials and Methods:

The study was carried out on the seeds of Sorghum bicolor for 72 h. The mean radicle length (mm) of the seeds was taken at 48 and 72 h.

Result:

The result showed that when compared with the control, methotrexate, the standard drug showed a significant (P < 0.001) anti-proliferative effect throughout the experiment. The inhibition of the radicle growth was more after 72 h (87.42%). At a dose of 5% (v/v), the juice showed a slightly significant (P < 0.05) effect affect after 72 h; however, there was no significant effect at 48 h. The juice at doses of 10% and 20% (v/v) showed a highly significant (P < 0.001) anti-proliferative effect throughout the experiment; however, the percentage inhibitions were higher at 72 h. At 72 h, the percentage inhibition for juice at 10% (v/v) was 72.37% and at 20% (v/v) was 91.96%. The concentrations of 40% and 60% (v/v) showed cytostatic effects as no appreciable growth of the radicles of the seeds was observed throughout the experiment. The percentage inhibition for 40% (v/v) was 100% and 99.72% for 48 and 72 h, respectively, while that for the juice concentration of 60% (v/v) was 100% throughout the study.

Conclusion:

The experiment has shown that C. sinensis fruit juice has a potential for causing both anti-proliferative and cytostatic effects on fast proliferating cells and hence cancerous cells.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4181126

DOI: 10.4103/2229-516X.140711
PubMed: 25298937
PubMed Central: 4181126

Affiliations:

Nigeria

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<front><div type="abstract" xml:lang="en"><sec id="st1"><title>Aim:</title>
<p>This work has been designed to evaluate the anti-proliferative and cytostatic effects of <italic>Citrus sinensis</italic>
 (orange) fruit juice on rapidly proliferating cells.</p>
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<sec id="st2"><title>Materials and Methods:</title>
<p>The study was carried out on the seeds of Sorghum bicolor for 72 h. The mean radicle length (mm) of the seeds was taken at 48 and 72 h.</p>
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<p>The result showed that when compared with the control, methotrexate, the standard drug showed a significant (<italic>P</italic>
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 < 0.05) effect affect after 72 h; however, there was no significant effect at 48 h. The juice at doses of 10% and 20% (v/v) showed a highly significant (<italic>P</italic>
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<p>The experiment has shown that <italic>C. sinensis</italic>
 fruit juice has a potential for causing both anti-proliferative and cytostatic effects on fast proliferating cells and hence cancerous cells.</p>
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Evaluation of the anti-proliferative and cytostatic effect of Citrus sinensis (orange) fruit juice

Evaluation of the anti-proliferative and cytostatic effect of Citrus sinensis (orange) fruit juice

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